Sharktopus (2010)

Aiming to create the U.S. Navy's next hyper-weapon while fiddling with both shark and octopus DNA, the visionary geneticist Dr. Nathan Sands comes up with a nightmarish prototype: the genetically enhanced "S-11" hybrid. However, after a botched attempt to harness the creature, the unstoppable beast escapes into the warm waters of Puerto Vallarta, Mexico where unsuspecting tourists and unaware locals alike become its next meal. Now the government wants its monster back, and former mercenary Andy Flynn, along with Sands' daughter, Nicole and fisherman Santos, seem to be the only ones cut out for the job. Can they stop the sharktopus, the underwater killer with the razor-sharp teeth and the tentacles of death, before it slaughters everybody in the seaside resort?—Nick Riganas